ITCH Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 209201AP
DescriptionAtrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|AIF4, AIP4, ITCH, NAPP1, NFE2 associated polypeptide 1|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|ITCH Fusion Protein Ag15120|
|Antigen Affinity Chromatography|
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