Tocris™ ITD 1

Selective inhibitor of TGF-beta signaling; induces cardiomyocyte differentiation in ESCs

Manufacturer: Tocris™ 5068/50

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Catalog No. 50-685-0R

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For Research Use Only


    Inhibitors ITD 1
    Purity >98
    Molecular Weight 415.52
    Quantity 50mg
    Product Type ITD 1

    Selective inhibitor of TGF-β signaling (IC50 = 0.85µM); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF-β type II receptor. Inhibits TGF-β-induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells.

    • Chemical Name: 4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester
    • Formula: C27H29NO3
    • CAS Number: 1099644-42-4
    • Solubility: Soluble to 20mM in DMSO and to 10mM in ethanol with gentle warming
    • Purity: >98

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