Tocris ITD 1
Selective inhibitor of TGF-beta signaling; induces cardiomyocyte differentiation in ESCs
Manufacturer: Tocris 5068/10
DescriptionSelective inhibitor of TGF-β signaling (IC50 = 0.85µM); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF-β type II receptor. Inhibits TGF-β-induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells.
- Chemical Name: 4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester
- Formula: C27H29NO3
- CAS Number: 1099644-42-4
- Solubility: Soluble to 20mM in DMSO and to 10mM in ethanol with gentle warming
- Purity: >98
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