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ITFG2 Mouse anti-Human, Clone: OTI3G4, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA503048

Catalog No. 50-167-4021


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Description

Description

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Specifications

Specifications

ITFG2
Monoclonal
0.36 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q969R8
FGGAP1, MDS028
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
55846
Western Blot
OTI3G4
Unconjugated
ITFG2
Liquid
ITFG2
Full length human recombit protein of human ITFG2 produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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