ITFG2 Mouse anti-Human, Non-human primate, Rat, Clone: OTI3A3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525576
DescriptionAs part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|MDS028, integrin-alpha FG-GAP repeat-containing protein 2|
|-20° C, Avoid Freeze/Thaw Cycles|
|362441, 55846, 708596|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of ITFG2 produced in HEK293T cell|
|Human, Non-human primate, Rat|
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