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ITGB1BP1 Mouse anti-Human, Clone: OTI6A12, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526620

Catalog No. PIMA526620


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Description

Description

Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin.
Specifications

Specifications

ITGB1BP1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O14713
Bodenin; ITGB1BP1; bodenin; DKFZp686K08158; ICAP-1; ICAP-1alpha; ICAP-1B; ICAP1ICAP1AICAP1BICAP-1A; integrin beta 1 binding protein 1; integrin beta-1-binding protein 1; Integrin cytoplasmic domain-associated protein 1; integrin cytoplasmic domain-associated protein 1-alpha; integrin cytoplasmic domain-associated protein 1-beta
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
9270
Immunohistochemistry (Paraffin), Western Blot
OTI6A12
Unconjugated
ITGB1BP1
Liquid
ITGB1BP1
Full length human recombit protein of ITGB1BP1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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