ITIH4 Mouse anti-Human, Clone: CL1858, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524630
Immunogen sequence: LAYSFVTPLT SMVVTKPDDQ EQSQVAEKPM EGESRNRNVH SAGAAGSRMN FRPGVLSSRQ LGLPGPPDVP DHAAYHPFRR LAILPASAPP ATSNPDPAVS RVMNMKIEET TMTTQTPA Highest antigen sequence identity to the following orthologs: Mouse - 35%, Rat - 36%. Binds to an epitope located within the peptide sequence LSSRQLGLPGPPDVP as determined by overlapping synthetic peptides.the inter-alpha-trypsin inhibitor (ITI, I-alpha-I) family, a typical and classical example for protein-glycosaminoglycoprotein (PGP) complexes, occurs constitutively in plasma at relatively high concentrations and is a result of alternate combinations of three kinds of heavy chains with a common light chain, the bikunin proteoglycan. Bikunin has two proteinase inhibotor domains and belongs to the Kunitz-type protease inhibitor family; it displays an inhibitory activity against trypsin, leukocyte elastase and plasmin. The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid and this binding promotes the stability of the extra-cellular matrix. The ITI protein family is suspected of playing a key role in the extra-cellular matrix biology.
|PBS with 40% glycerol and 0.02% sodium azide; pH 7.2|
|DKFZp686G21125, H4P, IHRP, ITIHL1, PK120|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Immunohistochemistry, Western Blot|
|Recombit protein corresponding to Human ITIH4|
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