ITM2B Mouse anti-Human, Clone: OTI1C11, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525513
DescriptionAmyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|ITM2B; integral membrane protein 2B; ABRI; BRI; BRI2; BRICD2B; E25B; E3-16; FBD; BRICHOS domain containing 2B; OTTHUMP00000018394|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of ITM2B produced in HEK293T cell|
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