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ITM2B Mouse anti-Human, Clone: OTI1C11, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525513

Catalog No. PIMA525513


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Description

Description

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
Specifications

Specifications

ITM2B
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9Y287
ITM2B; integral membrane protein 2B; ABRI; BRI; BRI2; BRICD2B; E25B; E3-16; FBD; BRICHOS domain containing 2B; OTTHUMP00000018394
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
9445
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
OTI1C11
Unconjugated
ITM2B
Liquid
ITM2B
Full length human recombit protein of ITM2B produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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