Tocris IWP 12
Potent PORCN inhibitor; active in vivo
Manufacturer: Tocris 5279/50
DescriptionPotent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 15nM). Inhibits Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. Blocks zebrafish tailfin regeneration in vivo.
- Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]acetamide
- Formula: C18H18N4O2S3
- CAS Number: 688353-45-9
- Solubility: Soluble to 100mM in DMSO
- Purity: >98
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