Tocris™ J 147

Neuroprotective and neurotrophic compound; reduces Abeta40 and Abeta42 levels

Manufacturer: Tocris™ 5081/50

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Catalog No. 508150R

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For Research Use Only


    Product Type J 147
    Inhibitors J 147
    Purity >99
    Molecular Weight 350.33
    Quantity 50mg

    Potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's Disease mice, respectively. Orally active.

    • Chemical Name: 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
    • Formula: C18H17F3N2O2
    • CAS Number: 1146963-51-0
    • Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
    • Purity: >99

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