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  7. JLK 6, Tocris Bioscience™

JLK 6, Tocris Bioscience™

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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
62252-26-0
C10H8ClNO3
225.628
AMDGKLWVCUXONP-UHFFFAOYSA-N
7-amino-4-chloro-3-methoxyisocoumarin, jlk 6, jlk6, 7-amino-4-chloro-3-methoxy-isocoumarin, gamma-secretase inhibitor xi, 1h-2-benzopyran-1-one, 7-amino-4-chloro-3-methoxy, jlk-6, 3-methoxy-4-chloro-7-aminoisocoumarin, 7-amino-3-methoxy-4-chloroisocoumarin, 7-amino-4-chloro-3-methoxy-1h-2-benzopyran
3803
7-amino-4-chloro-3-methoxyisochromen-1-one
COC1=C(C2=C(C=C(C=C2)N)C(=O)O1)Cl
This item is not returnable. View return policy
62252-26-0
C10H8ClNO3
225.628
AMDGKLWVCUXONP-UHFFFAOYSA-N
7-amino-4-chloro-3-methoxyisocoumarin, jlk 6, jlk6, 7-amino-4-chloro-3-methoxy-isocoumarin, gamma-secretase inhibitor xi, 1h-2-benzopyran-1-one, 7-amino-4-chloro-3-methoxy, jlk-6, 3-methoxy-4-chloro-7-aminoisocoumarin, 7-amino-3-methoxy-4-chloroisocoumarin, 7-amino-4-chloro-3-methoxy-1h-2-benzopyran
3803
7-amino-4-chloro-3-methoxyisochromen-1-one
COC1=C(C2=C(C=C(C=C2)N)C(=O)O1)Cl

Description

Inhibitor of γ-secretase-mediated βAPP processing

Inhibitor of γ-secretase that selectively inhibits βAPP cleavage without affecting other γ-secretase-mediated pathways. Prevents recovery of Aβ40 and Aβ42 from HEK293 cell overexpressing wild-type or Swedish-mutated βAPP (IC50 ∽ 30 μM) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α-secretase, the proteosome or GSK3β.
Quantity 10 mg
Formula Weight 225.63
Percent Purity >99%
Chemical Name or Material JLK 6

Safety and Handling

Recommended Storage : Store at Room Temperature