JMJD2B Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5120953

Catalog No. PIPA5120953

Description

Positive test controls include: Mouse brain. The target is usually found in the following locations: Nucleus. Immunogen sequence: MGSEDHGAQN PSCKIMTFRP TMEEFKDFNK YVAYIESQGA HRAGLAKIIP PKEWKPRQTY DDIDDVVIPA PIQQVVTGQS GLFTQYNIQK KAMTVGEYRR LANSEKYCTP RHQDFDDLER KYWKNLTFVS PIYGADISGS LYDDDVAQWN IGSLRTILDM VERECGTIIE GVNTPYLYFG MWKTTFAWHT EDMDLYSINY LHFGEPKSWY AIPPEHGKRL ERLAIGFFPG SSQGCDAFLR HKMTLISPII LKKYGIPFSR ITQEAGEFMI TFPYGYHAGF NHGFNCAEST NFATLRWIDY GKVATQCTCR KDMVKISMDV FVRILQPERY ELWKQGKDLT VLDHTRPTAL TSPELSSWSA SRASL

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. [UniProt]

Specifications

• Antigen: JMJD2B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KDM4B
• Gene Alias: 4732474L06Rik; JHDM3B; JmjC domain-containing histone demethylation protein 3B; Jmjd2b; jumonji domain containing 2B; jumonji domain-containing protein 2B; KDM4B; KIAA0876; lysine (K)-specific demethylase 4B; lysine demethylase 4B; lysine-specific demethylase 4B; mKIAA0876; TDRD14B; tudor domain containing 14B
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 193796, 23030
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 1.58 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O94953, Q91VY5
• Gene Symbols: KDM4B
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human KDM4B/JMJD2B (NP_0558301)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov