Tocris™ JNJ 27141491

Potent and selective human CCR2 antagonist

Manufacturer: Tocris™ 5176/10

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Catalog No. 51-761-0

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For Research Use Only


    Description JNJ 27141491
    Molecular Weight 379.38
    Purity >98
    Quantity 10mg
    Product Type JNJ 27141491

    Potent, noncompetitive human CCR2 antagonist; inhibits MCP-1-induced Ca2+ mobilization in hCCR2-CHO cells (IC50 = 13nM). Exhibits selectivity for CCR2 over CCR1, CCR3-8 and CXCR1-3. Delays onset and reduces neurological signs in an experimental autoimmune encephalomyelitis model of multiple sclerosis in hCCR2 knock-in mice. Orally active.

    • Chemical Name: 3-[(1S)-1-(3,4-Difluorophenyl)propyl]-2,3-dihydro-5-(5-isoxazolyl)-2-thioxo-1H-imidazole-4-carboxylic acid methyl ester
    • Formula: C17H15F2N3O3S
    • CAS Number: 871313-59-6
    • Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
    • Purity: >98

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