Tocris™ JNJ 47965567

Potent and selective P2X7 antagonist; brain penetrant

Manufacturer: Tocris™ 5299/50

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Catalog No. 52-995-0

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For Research Use Only


    Product Type JNJ 47965567
    Inhibitors JNJ 47965567
    Purity >98
    Molecular Weight 488.64
    Quantity 50mg

    Potent and selective P2X7 antagonist (pIC50 values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively). Selective over a panel of 50 other receptors, ion channels and transporters. Reduces BzATP-induced IL-1β release from monocytes in vitro and from rat brain in vivo. Attenuates amphetamine-induced hyperactivity in rats. Brain penetrant.

    • Chemical Name: 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide
    • Formula: C28H32N4O2S
    • CAS Number: 1428327-31-4
    • Solubility: Soluble to 50mM in 1eq. HCl and to 100mM in DMSO
    • Purity: >98

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