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JPH2 Mouse anti-Human, Clone: OTI2D3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526300

Catalog No. PIMA526300


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Description

Description

Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predomitly expressed in the brain and contribute to the subsurface cistern formation in neurons. JPH2-null mice died of embryonic cardiac arrest and human patients with mutations in the JPH2 gene showed hypertrophic cardiomyopathy, demonstrating the importance of this protein. Multiple isoforms of JPH2 are known to exist.
Specifications

Specifications

JPH2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9BR39
CMH17, JP-2, JP2; junctophilin type 2; junctophilin-2
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
57158
Western Blot
OTI2D3
Unconjugated
JPH2
Liquid
JPH2
Full length human recombit protein of JPH2 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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