Tocris™ JW 67

Wnt pathway inhibitor; induces degradation of active beta-catenin

Manufacturer: Tocris™ 4651/50

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Catalog No. 46-515-0R

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For Research Use Only


    Inhibitors JW 67
    Purity >97
    Molecular Weight 394.38
    Quantity 50mg
    Product Type JW 67

    Inhibitor of canonical Wnt pathway signaling (IC50 = 1.17µM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-κB pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8µM).

    • Chemical Name: Trispiro[3H-indole-3,2'-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione
    • Formula: C21H18N2O6
    • CAS Number: 442644-28-2
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >97

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