Tocris JW 67
Wnt pathway inhibitor; induces degradation of active beta-catenin
Manufacturer: Tocris 4651/10
DescriptionInhibitor of canonical Wnt pathway signaling (IC50 = 1.17µM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-κB pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8µM).
- Chemical Name: Trispiro[3H-indole-3,2'-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione
- Formula: C21H18N2O6
- CAS Number: 442644-28-2
- Solubility: Soluble to 100mM in DMSO
- Purity: >97
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