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Tocris Bioscience™ JW 74

Wnt pathway inhibitor

$154.90 - $625.50

Specifications

Formula Weight Observed MW: 456.52
Chemical Name or Material 4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine
Molecular Formula C24H20N6O2S
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
565310 View Documents Tocris Bioscience™
5653/10
10mg Each for $154.90
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565350 View Documents Tocris Bioscience™
5653/50
50mg Each for $625.50
Add to cart
 
Description

Description

Inhibitor of canonical Wnt signaling (IC50 = 790 nM). Targets the β-catenin destruction complex (GSK-3?/AXIN/APC). Increases AXIN2 and decreases active β-catenin levels in colorectal cancer (CRC) cells. Also arrests cell cycle in G1 and inhibits proliferation of CRC cells in vitro. Inhibits tumor growth and formation in mouse models.
Specifications

Specifications

Observed MW: 456.52
4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine
C24H20N6O2S
Safety and Handling

Safety and Handling

Recommended Storage : Store at +4°C

For Research Use Only

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