Tocris K 02288
Type 1 BMP receptor inhibitor
Manufacturer: Tocris 4986/10
DescriptionPotent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC50 = 100nM) and induces dorsalization of zebrafish embryos.
- Chemical Name: 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
- Formula: C20H20N2O4
- CAS Number: 1431985-92-0
- Solubility: Soluble to 100mM in DMSO and to 10mM in ethanol with gentle warming
- Purity: >99
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