Tocris K 858
Selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor
Manufacturer: Tocris 3703/10
DescriptionSelective ATP-uncompetitive mitotic kinesin Eg5 inhibitor (IC50 = 1.3µM). Induces mitotic arrest, caspase-3 activation and cell growth inhibition in HCT116 cells. Displays no effect on microtubule dynamics. Preferentially induces mitotic arrest in cancer cells.
- Chemical Name: N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
- Formula: C13H15N3O2S
- CAS Number: 72926-24-0
- Solubility: Soluble to 100mM in DMSO and to 10mM in ethanol
- Purity: >99
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