Tocris Bioscience™ Kainic acid

Kainate agonist; excitant and neurotoxin

Supplier:  Tocris Bioscience™ 0222/50

Catalog No. 02-225-0

Description

Kainic acid, also known as kainate, is a selective agonist of kainate ionotropic glutamate receptors (EC50 = 0.6 - 7.4 μM) and a partial agonist at AMPA receptors (EC50 = 31 μM - 170 μM). Kainic acid is used to model epilepsy in vivo and to study the mechanisms of neurodegeneration and neurocytosis induced by excess stimulation by kainic acid. Kainate is shown to be involved in amyloidogenic processing of amyloid precursor protein and Aβ peptides in Alzheimer's disease.

Related compounds include synthetic Kainic acid (Cat. No. 7065), the kainate receptor agonist Domoic acid (Cat. No. 0269) and the antagonist NBQX (Cat. No. 0373).

Specifications

• Chemical Name or Material: (2 S,3 S,4 S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid
• Assay Percent Range: >98%
• Solubility: Soluble to 25 mM in water with gentle warming
• Molecular Formula: C₁₀H₁₅NO₄
• Purity: 98%

• CAS: 487-79-6
• Quantity: 50 mg
• Target: Kainate Receptor Agonists
• Formula Weight: Observed MW: 213.23

Safety and Handling

Recommended Storage : Store at Room Temperature

For Research Use Only