Invitrogen™ Kalirin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536953

Catalog No. PIPA536953

Description

This antibody detects endogenous protein at a molecular weight of 192 and 350 kDa. Purity is >95% by SDS-PAGE.

HAP1 (huntingtin-associated protein 1) binds to huntingtin. Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington's disease (HD). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region. HAP1 shows neuronal localization and moves with huntingtin in nerve fibers. HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem. Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons. Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.

Specifications

• Antigen: Kalirin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KALRN
• Gene Alias: 2210407G14Rik; ARHGEF24; AV235988; CHD5; CHDS5; cyclin B1; DUET; DUO; E530005C20Rik; FLJ12332; FLJ16443; FLJ18196; FLJ18623; Gm539; HAPIP; hCG_2022551; huntingtin-associated protein interacting protein (duo); huntingtin-associated protein-interacting protein; Kalirin; kalirin, RhoGEF kinase; kalrn; PAM COOH-terminal interactor protein 10; P-CIP10; Protein Duo; RhoGEF kinase; serine/threonine kinase with Dbl- and pleckstrin homology domain; serine/threonine kinase with Dbl- and pleckstrin homology domains; serine/threonine-protein kinase with Dbl- and pleckstrin homology domain; TRAD
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 545156, 84009, 8997
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: A2CG49, O60229, P97924
• Gene Symbols: KALRN
• Immunogen: Synthetic peptide corresponding to amino acids 895-940 of human KALRN.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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