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Invitrogen™ Kallikrein 6 Human ELISA Kit

Sandwich ELISA Kit

Manufacturer:  Invitrogen™ EHKLK6

Encompass

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Catalog No. EHKLK6


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Description

Description

The Human Kallikrein 6 (Hu KLK6) ELISA quantitates Hu KLK6 in human serum, plasma, or cell culture medium. The assay will exclusively recognize both natural and recombinant Hu KLK6. Principle of the method The Human KLK6 solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen. Rigorous validation Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Kallikrein 6, or KLK6, shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. It degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. KLK6 may be involved in regulation of axon outgrowth following spinal cord injury. KLK6 has also been shown to promote cell proliferation, migration, and invasion and is upregulated in several types of cancers including colon and ovarian cancers.
Specifications

Specifications

This ELISA pair antibody detects human KLK6. Other species not determined.
Colorimetric Microplate Reader
Solid-phase sandwich ELISA
GCPR
Q92876
0.6ng/mL to 150ng/mL
5653
RUO
2°C to 8°C
4 hr. 45 min.
Neurobiology
<12%
96 Tests
Plasma, Serum, Supernatant
Bssp,Klk7,PRSS18,PRSS9,SP59,hK6
96 assays
ELISA Kit
Biotin
HRP
0.614-150 ng/mL
ELISA, Protein Assays, Protein Biology, Cancer Biology, Immunology, Neuroscience, Neurobiology, Protein Detection, Protein Analysis
Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
Plasma, 50 μL; Serum, 50 μL; Supernatant, 100 μL
1 hr. 20 min.
Human
Bssp, Klk7, PRSS18, PRSS9, SP59, hK6
<10%
Human
0.6 ng/mL
SDS
Documents
Product Certifications
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