Kallikrein 8 Mouse anti-Human, Clone: OTI1D2, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526252
DescriptionKallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Kallikrein-8 (KLK8), also called neuropsin precursor, ovasin or serine protease 19, is a 260 amino acid secreted protein involved in hippocampal plasticity. Two isoforms exist for this protein. Isoform 1 is the primary form of KLK8 found predomitly in the pancreas. Isoform 2 contains an additional 46 amino acids after amino acid 23 and is predomitly expressed in adult brain and hippocampus. Isoform 2 is not common to the mouse homolog or other primate homologs. In humans, the T to A mutation (c.71-127T>A) leads to the splice variant seen in the human brain. Both isoforms are detected in fetal brain and placenta. In some cancer cells, KLK8 expression can suppress tumor cell invasiveness and lead to a favorable clinical outcome.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Kallikrein-8; Hk8; Neuropsin; Ovasin; Serine protease 19; Serine protease TADG-14; Tumor-associated differentially expressed gene 14 protein; KLK8; NRPN; PRSS19; TADG14; UNQ283; PRO322; Kallikrein 8; Kallikrein8|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of KLK8 produced in HEK293T cell|
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