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Kallikrein 8 Mouse anti-Human, Clone: OTI1D2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526252

Catalog No. PIMA526252


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Description

Description

Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Kallikrein-8 (KLK8), also called neuropsin precursor, ovasin or serine protease 19, is a 260 amino acid secreted protein involved in hippocampal plasticity. Two isoforms exist for this protein. Isoform 1 is the primary form of KLK8 found predomitly in the pancreas. Isoform 2 contains an additional 46 amino acids after amino acid 23 and is predomitly expressed in adult brain and hippocampus. Isoform 2 is not common to the mouse homolog or other primate homologs. In humans, the T to A mutation (c.71-127T>A) leads to the splice variant seen in the human brain. Both isoforms are detected in fetal brain and placenta. In some cancer cells, KLK8 expression can suppress tumor cell invasiveness and lead to a favorable clinical outcome.
Specifications

Specifications

Kallikrein 8
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O60259
Kallikrein-8; Hk8; Neuropsin; Ovasin; Serine protease 19; Serine protease TADG-14; Tumor-associated differentially expressed gene 14 protein; KLK8; NRPN; PRSS19; TADG14; UNQ283; PRO322; Kallikrein 8; Kallikrein8
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
11202
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI1D2
Unconjugated
KLK8
Liquid
KLK8
Full length human recombit protein of KLK8 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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