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KappaB ras1 Mouse anti-Human, Clone: OTI6C11, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526126

Catalog No. PIMA526126


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Description

Description

KappaB ras-1 (kappa-B-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with Ikappa-B (Ikappa-B), an inhibitor of the transcription factor NF-kappa-B. Ikappa-B exists in two homologous forms, Ikappa-B-alpha and Ikappa-B-beta, although Ikappa-B-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive Ikappa-B-alpha-NF-kappa-B complexes can shuttle in and out of the nucleus, Ikappa-B-beta-NF-kappa-B complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the Ikappa-B-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of Ikappa-B-beta and regulating the rate of degradation of Ikappa-B-beta. This antibody is specific for kappaB-ras1 and has no cross-reactivity to kappaB-ras2.
Specifications

Specifications

KappaB ras1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9NYS0
KBRAS1; kappaB-Ras1; I-kappa-B-interacting Ras-like protein 1; NF-kappa-B inhibitor-interacting Ras-like protein 1; NFKB inhibitor interacting Ras-like protein 1; kappa B-Ras protein 1; kappa B-ras 1
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
28512
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI6C11
Unconjugated
NKIRAS1
Liquid
NKIRAS1
Full length human recombit protein of NKIRAS1 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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