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KV2.2 (KCNB2) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549216

Catalog No. PA549216


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Description

Description

Predicted to react with bovine, mouse and rabbit based on sequence homology.

Kcnb2 (Kv2.2) encodes a Voltage-gated K+ channel which are important determits of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variation in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK) channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety on non-neuronal cell types including pancreatic islet , alveolar cells and cardiac myocytes. Kv2.1 and Kcnb2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells. Functionally, Kcnb2 mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Diseases associated with KCNB2 include Brugada Syndrome.
Specifications

Specifications

KV2.2 (KCNB2)
Polyclonal
PBS with 0.09% sodium azide
Q92953
Potassium voltage-gated channel subfamily B member 2, Voltage-gated potassium channel subunit Kv22, KCNB2
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
9312
Western Blot
Unconjugated
KCNB2
Liquid
KCNB2
KLH conjugated synthetic peptide between 138-166 amino acids from the N-terminal region of human KCNB2.
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human
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