Invitrogen™ KCNN2 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA519205

Catalog No. PIPA519205

Description

This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.

Action potentials in vertebrate neurons are followed by an afterhyperpolarization that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: KCNN2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Kcnn2
• Gene Alias: apamin-sensitive small-conductance Ca2+-activated potassium channel; fri; hSK2; KCa2.2; KCNN2; potassium calcium-activated channel subfamily N member 2; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2; potassium intermediate/small conductance calcium-activated channel type2; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; SK2; SKCa 2; SKCa2; small conductance calcium-activated channel, subfamily N, member 2; small conductance calcium-activated potassium channel 2; small conductance calcium-activated potassium channel protein 2; small conductance calcium-activated potassium channel protein 2-like; small conductance calcium-activated potassium channel subfamily N member 2; small conductance potassium channel type 2; small conductance potassium channel type2; small conductance potassium channel type2 variant2
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 3781
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9H2S1
• Gene Symbols: Kcnn2
• Immunogen: Synthetic peptide sequence (ESYDKHVTYNAER) corresponding to the internal amino acids of KCNN2 (aa 545-558).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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