KCTD13 Mouse anti-Human, Clone: OTI3B12, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527056
DescriptionCytochrome P450 super family proteins are monooxygenases which catalyze multiple biochemical reactions involved in drug metabolism and synthesis of cholesterol, steroids and lipids. CYP4F3, a 60KDa protein, is a novel member of this family. It consists of a conserved heme-binding domain near the C-terminus and catalyzes the u-hydroxylation of LTB4. CYP4F3 is localized in the ER and plays a vital role in the inactivation of LTB4 and controlling inflammation. CYP4F3 exists in two functionally distinct isoforms: CYP4F3A, a neutrophil isoform, is particularly expressed in neutrophils and myeloid cells and catalyzes the microsomal u-hydroxylation of LTB4. It interacts with CD11b and myeloperoxidase on myeloid cells and regulates cellular development in bone marrow. CYP4F3B, a liver isoform, catalyzes the conversion of arachidonic acid to 20-HETE, a potent activator of PKC. Itrole hasbeen implicatedin cell proliferation, vascular tone and natriuresis.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|KCTD13, BACURD1, FKSG86, PDIP1, POLDIP1, hBACURD1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of KCTD13 produced in E.coli|
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