KDEL Mouse anti-Chemical, Clone: 2D6, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527581
DescriptionThe sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble endoplasmic reticulum (ER) resident proteins and some membrane proteins. 78 and 94 kDa glucose regulated proteins, GRP78 and GRP94 respectively, and protein disulfide isomerase (PDI) all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
|PBS with 50% glycerol and 0.09% sodium azide; pH 7.4|
|KDEL, Lys Asp Glu Leu, Lys-Asp-Glu-Leu (KDEL), Lys-Asp-Glu-Leu, Lysine-aspartic acid-glutamate-leucine|
|KDEL peptide (C-AVKDEL -COOH) conjugated at the N-terminal to Bovine Serum Albumin (BSA)|
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