KDM1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 208131AP
DescriptionLSD1 is a histone demethylase that specifically demethylates ft.Lys-4 ft. of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted ft.Lys-4 ft. of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 ft.Lys-4 ft. on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate ft.Lys-9 ft. of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|AOF2, BHC110, KDM1, KDM1A, KIAA0601, LSD1, lysine (K) demethylase 1|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|KDM1 Fusion Protein Ag14778|
|Antigen Affinity Chromatography|
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