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KDM1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 208131AP

Catalog No. 50-173-3104


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Description

Description

LSD1 is a histone demethylase that specifically demethylates  ft.Lys-4 ft. of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted  ft.Lys-4 ft. of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3  ft.Lys-4 ft. on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate  ft.Lys-9 ft. of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.
Specifications

Specifications

KDM1
0.35 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O60341, Q6ZQ88
AOF2, BHC110, KDM1, KDM1A, KIAA0601, LSD1, lysine (K) demethylase 1
Rabbit
IgG
150 μL
-20°C
Primary
23028, 99982
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
KDM1A
Liquid
Kdm1a
KDM1 Fusion Protein Ag14778
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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