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KDM5A Mouse anti-Human, Active Motif™ Non-distribution product as customer accommodation.

Mouse Recombinant Monoclonal Antibody

$98.40 - $465.85

Specifications

Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Antigen KDM5A
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-3746 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
91212
10 μg
Each for $98.40
Add to cart
 
50-199-3745 Non-distribution product as customer accommodation.
View Documents
Active MotifSupplier Diversity Partner
91211
100 μg
Each for $465.85
Add to cart
 
Description

Description

UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctionsThis gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.
Specifications

Specifications

Monoclonal
Primary
KDM5A
Unconjugated
SDS
Product Certifications
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