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KDM5B Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550693

Catalog No. PA550693


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Description

Description

The antibody detects endogenous levels of total KDM5B protein.

KDM5B is a histone demethylase that demethylates  ft.Lys-4 ft. of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3  ft.Lys-9 ft. or H3  ft.Lys-27 ft.. KDM5B demethylates trimethylated, dimethylated and monomethylated H3  ft.Lys-4 ft.. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.
Specifications

Specifications

KDM5B
Polyclonal
Unconjugated
KDM5B
Liquid
KDM5B
Synthetic peptide corresponding to a region derived from internal residues of human lysine (K)-specific demethylase 5B
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
2.7 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q9UGL1, Q80Y84
JARID1B, PLU1, RBBP2H1
Rabbit
IgG
100 μL
-20°C
Primary
10765, 75605
Documents
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