KDM5B Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA550693
The antibody detects endogenous levels of total KDM5B protein.KDM5B is a histone demethylase that demethylates ft.Lys-4 ft. of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 ft.Lys-9 ft. or H3 ft.Lys-27 ft.. KDM5B demethylates trimethylated, dimethylated and monomethylated H3 ft.Lys-4 ft.. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.
|Synthetic peptide corresponding to a region derived from internal residues of human lysine (K)-specific demethylase 5B|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 50% glycerol and 0.05% sodium azide; pH 7.3|
|JARID1B, PLU1, RBBP2H1|
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