Tocris Ki 16425
LPA1 and LPA3 receptor antagonist
Manufacturer: Tocris 5056/10
DescriptionAntagonist of the lysophosphatidic acid receptors LPA1 and LPA3 (Ki values are 0.25 and 0.36µM respectively, in a GTPγS binding assay). Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway, in HEK293A cells.
- Chemical Name: 3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]propanoic acid
- Formula: C23H23ClN2O5S
- CAS Number: 355025-24-0
- Solubility: Soluble to 100mM in DMSO and to 20mM in 1eq. NaOH
- Purity: >98
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