Tocris™ Ki 16425

LPA1 and LPA3 receptor antagonist

Manufacturer: Tocris™ 5056/50

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Catalog No. 505650R

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For Research Use Only


    Inhibitors Ki 16425
    Purity >98
    Molecular Weight 474.96
    Quantity 50mg
    Product Type Ki 16425

    Antagonist of the lysophosphatidic acid receptors LPA1 and LPA3 (Ki values are 0.25 and 0.36µM respectively, in a GTPγS binding assay). Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway, in HEK293A cells.

    • Chemical Name: 3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]propanoic acid
    • Formula: C23H23ClN2O5S
    • CAS Number: 355025-24-0
    • Solubility: Soluble to 100mM in DMSO and to 20mM in 1eq. NaOH
    • Purity: >98

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