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KIAA1524 Mouse anti-Human, Clone: OTI9E6, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF808455

Catalog No. 50-166-8869


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human maligcies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.
Specifications

Specifications

KIAA1524
Monoclonal
Unconjugated
CIP2A
KIAA1524, p90
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
57650
Immunohistochemistry (Paraffin), Western Blot
OTI9E6
PBS with 8% trehalose and no preservative; pH 7.3
Lyophilized
CIP2A
Human recombit protein fragment corresponding to amino acids 635-905 of human KIAA1524 produced in E.coli.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
SDS
Documents
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