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Kindlin 3 Mouse anti-Human, Clone: OTI2G2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526932

Catalog No. PIMA526932


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Description

Description

The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.
Specifications

Specifications

Kindlin 3
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q86UX7
FERMT3; fermitin family homolog 3 (Drosophila); KIND3; MGC10966; MIG-2; MIG2B; UNC112C; URP2; URP2SF; UNC-112 related protein 2; fermitin family homolog 3; kindlin 3; kindlin-3
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
83706
Immunohistochemistry (Paraffin), Western Blot
OTI2G2
Unconjugated
FERMT3
Liquid
FERMT3
Human recombit protein fragment corresponding to amino acids 259-528 of FERMT3 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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