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Kir2.1 (KCNJ2) Mouse anti-Human, Mouse, Rat, Rhesus Monkey, Clone: S112B-14, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527681

Catalog No. PIMA527681



Description

Description

The KIR2 subunit family includes 2.1, 2.2, 2.3 and 2.4. Unlike G protein-coupled KIR3 subunits, KIR2.1 requires both phosphorylation by PKA and ATP hydrolysis for functional activity. KIR2.1 is expressed in the superior and inferior collicula and the pontine region of the brain, where it moderates synaptic transmission, like many other potassium channels. In the placenta, KIR2.1 is expressed throughout gestation in cytotrophoblast cells. In the kidney, KIR2.1 colocalizes with KIR5.1 in the proximal tubule. KIR2.1, 2.2 and 2.3 associate with the membrane-associated guanylate kinase synapseassociated protein 97 in the cerebellum and heart. Phosphorylation of KIR2.2 by protein kinase A inhibits the associates with SAP97.
Specifications

Specifications

Kir2.1 (KCNJ2)
Monoclonal
1 mg/ml
PBS with 50% glycerol and 0.09% sodium azide; pH 7.4
P35561, P63252, Q64273
HHBIRK1, HHIRK1, HIRK 1, IRK1, KCNJ2, LQT7, SQT3, potassium inwardly rectifying channel J2
Mouse
IgG1
100 μg
-20°C
Primary
16518, 29712, 3759, 574189
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
S112B-14
Unconjugated
KCNJ2
Liquid
Kcnj2
Fusion protein amino acids 41-64 and 189-428 of mouse Kir2.1
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat, Rhesus Monkey
Documents
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