KIR2DL4 Mouse anti-Human, PE, Clone: No.33, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen A15790
DescriptionKiller cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
|PBS with 0.2% BSA and 15mM sodium azide|
|CD158D, G9P, KIR103, KIR103AS, CD158 antigen-like family member D, KIR-103AS, MHC class I NK cell receptor KIR103AS, NK cell receptor, killer Ig receptor, killer cell immunoglobulin-like receptor 2DL4, killer cell inhibitory receptor 103AS, natural killer cell inhibitory receptor|
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