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KIR3DL3/CD158z Rabbit anti-Human, Alexa Fluor 647, Clone: 1136B, R&D Systems™

Recombinant Monoclonal Antibody

Manufacturer:  R&D Systems FAB8919R025

Catalog No. FAB8919R025


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Description

Description

KIR3DL3 is a member of the Killer-Immunoglobulin-like Receptor (KIR) family, a functionally diverse family of transmembrane receptors expressed primarily on NK cells. KIR3DL3 is a “framework” KIR gene, and is present in all individuals, in contrast to non-framework KIRs, whose gene content varies by KIR haplotype. KIR3DL3 is expressed at low or undetectable levels in peripheral blood NK cells, but expression can be induced in NK cell lines by demethylation agents, indicating that promoter DNA methylation inhibits KIR3DL3 transcription. Despite the lack of evidence for surface protein expression, KIR3DL3 mRNA expression has been detected in both decidual and peripheral blood NK cells in normal, disease-free conditions. Over amino acids (aa) 1-322, human KIR3DL3 shares 47% aa sequence identity with mouse KIR3DL1.
Specifications

Specifications

KIR3DL3/CD158z
1136B
Flow Cytometry 5 uL/10^6 cells
Q8N743
KIR3DL3
Human embryonic kidney cell line HEK293-derived recombinant human KIR3DL3/CD158z Met1-Leu322 Accession # Q8N743
Protein A or G purified from cell culture supernatant
RUO
Primary
115653
Human
Flow Cytometry
Alexa Fluor 647
Supplied in a saline solution containing BSA and Sodium Azide. with Sodium Azide
Purified
Rabbit
IgG
25 Tests
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 degreesC as supplied.
Monoclonal
Detects human KIR3DL3/CD158z in direct ELISAs.
SDS
Documents
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