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KISS1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550513

Catalog No. PA550513


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Description

Description

The antibody detects endogenous levels of total KISS1 protein.

This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in maligt melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.
Specifications

Specifications

KISS1
Polyclonal
Unconjugated
KISS1
Liquid
KISS1
Synthetic peptide corresponding to residues near the C terminal of human KiSS-1 metastasis-suppressor
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
0.2 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q15726, Q6Y4S4
HH13, KiSS-1
Rabbit
IgG
100 μL
-20°C
Primary
280287, 3814
Documents
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