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KLF11 Mouse anti-Human, Clone: OTI4H7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527382

Catalog No. PIMA527382


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Description

Description

KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. KLF10 is a transcriptional repressor involved in the regulation of cell growth and inhibits cell growth. It binds to the consensus sequence 5 ft.-GGTGTG-3 ft. and is induced by TGF-beta thus playing a role in linking TGF-beta-mediated signaling cascades to the regulation of pancreatic epithelial cell growth. KLF10 is involved in inducing and promoting apoptosis through the mitochondrial apoptotic pathway and may inhibit Smad7 expression in bronchial epithelial cells. Ubiquitous expression of KLF10 is seen in most of the tissues. Reports suggest that it may mediate up-regulation of TGFBI in VHL-deficient tumors and other cancers. Over expression of KLF10 may be associated with renal clear cell carcinoma and other tumors. KLF11 is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.
Specifications

Specifications

KLF11
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O14901
FKLF, FKLF1, MODY7, TIEG2, Tieg3, Krueppel-like factor 11, TGFB-inducible early growth response protein 2, TIEG-2, transforming growth factor-beta-inducible early growth response protein 2
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8462
Western Blot
OTI4H7
Unconjugated
KLF11
Liquid
KLF11
Human recombit protein fragment corresponding to amino acids 1-274 of KLF11 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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