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Tocris™ KRCA 0008

Potent Ack1 and ALK dual inhibitor; orally bioavailable

Manufacturer:  Tocris™ 5098/50

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Catalog No. 50-985-0R

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For Research Use Only



Potent Ack1 and anaplastic lymphoma kinase (ALK) dual inhibitor (IC50 values are 4 and 12nM respectively). Inhibits lung cancer H3122 cell proliferation (IC50 = 80nM). Attenuates H3122 cell xenograft tumor growth in mice. Orally bioavailable.
  • Chemical Name: 1,1'-[(5-Chloro-2,4-pyrimidinediyl)bis[imino(3-methoxy-4,1-phenylene)-4,1-piperazinediyl]]bisethanone
  • Formula: C30H37ClN8O4
  • CAS Number: 1472795-20-2
  • Solubility: Soluble to 100mM in 1eq. HCl and to 100mM in DMSO and to 100mM in ethanol
  • Purity: >99
Description & Specifications


KRCA 0008
KRCA 0008
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