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KSR2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA548202

Catalog No. PA548202

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
Specifications

Specifications

KSR2
Polyclonal
PBS with 0.09% sodium azide
Q6VAB6
Kinase suppressor of Ras 2, hKSR2, KSR2
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
283455
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
KSR2
Liquid
KSR2
KLH conjugated synthetic peptide between 603-638 amino acids from the C-terminal region of human KSR2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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