Epredia™ Lab Vision™ Ku (p70/p80) Ab-3 Mouse Monoclonal Antibody, 200μg/mL, BSA and azide

Recommended for multiple molecular biology techniques, Epredia™ Ku (p70/p80) Ab-3, Mouse Monoclonal Antibody provides accurate, reproducible results.

Supplier:  Epredia™ MS286R1

Catalog No. MS286R1

Description

The Ku autoantigen is a heterodimer of 70kDa (p70) and ∽80kDa (p80) proteins. The p70/p80 dimer is important for function of a 460kDa DNA-dependent protein kinase that phosphorylates certain transcription factors, including Sp1, Oct-1, p53, and SV40 large T antigen in vitro. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.

Host Species: Mouse

Clone: 162

Isotype: IgG2a

Species Reactivity: Human, Monkey, Xenopus. Mouse and Rat (Immunoprecipitation only). Does not react with cow and rabbit.

Epitope: A conformational epitope of p70/p80 dimer, which is destroyed during Western Blotting

Immunogen: Human B-cell nuclei from plasmacytoid 2p68 cells

Molecular Weight: 70kDa and 80kDa

Positive Control: Tonsil

Cellular Localization: Nuclear

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting (Not suitable)
• Immunofluorescence
• Affinity Purification
• Flow Cytometry
• Gel Supershift

General References:

1. Wang J, et. al. Molecular Biology Reports, 1993, 18(1):15-28.

2. Reeves WH, et. al. Journal of Experimental Medicine, 1985, 161(1):18-39.

Specifications

• Antigen: Ku (p70/p80) Ab-3
• Classification: Monoclonal
• Conjugate: Unconjugated
• Host Species: Mouse
• Quantity: 1 mL
• Research Discipline: DNA Repair
• Target Species: Human, Non-human Primate, Xenopus species
• Isotype: IgG2a

• Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin)
• Clone: 162
• Formulation: Ready-to-use for IHC (UVLP)
• Immunogen: Human B cell nuclei from plasmacytoid 2p68 cells
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Prediluted