Ku70/XRCC6 Mouse anti-Human, Primate, Chicken, Mouse, Rat, Alexa Fluor™ 594, Clone: KU729, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP234663AF594

Catalog No. NP234663A94

Description

Ku70/XRCC6 Monoclonal specifically detects Ku70/XRCC6 in Human, Primate, Chicken (Negative), Mouse (Negative), Rat (Negative) samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Flow (Intracellular).

Specifications

• Antigen: Ku70/XRCC6
• Classification: Monoclonal
• Conjugate: Alexa Fluor 594
• Formulation: 50 mM sodium borate with 0.05% sodium azide
• Gene Symbols: XRCC6
• Immunogen: Nuclear extract of human HL-60 cells
• Quantity: 0.1 mL
• Gene ID (Entrez): 2547
• Target Species: Human, Primate, Chicken, Mouse, Rat
• Isotype: IgG1 κ

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence
• Clone: KU729
• Dilution: Flow Cytometry, Immunocytochemistry/Immunofluorescence, Flow (Intracellular)
• Gene Alias: 5′-deoxyribose-5-phosphate lyase Ku70, 5′-dRP lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, CTC box binding factor 75 kDa subunit, CTC box-binding factor 75 kDa subunit, CTC75, CTCBF, D22S731, EC 3.6.4.-, EC 4.2.99.-, G22P1Ku70, Ku autoantigen p70 subunit, Ku autoantigen, 70kDa, KU70, ML8,70 kDa subunit, Thyroid-lupus autoantigen, thyroid-lupus autoantigen p70, TLAAD22S671, X-ray repair complementing defective repair in Chinese hamster cells 6DNA repair protein XRCC6, X-ray repair cross-complementing protein 6
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Primary or Secondary: Primary
• Test Specificity: Recognizes a dimer of two proteins of 70kDa and ~80kDa, identified as two subunits of Ku. This monoclonal antibody recognizes a conformational epitope of p70/p80 dimer, which is destroyed during Western blotting. The p70/p80 dimer is important for function of a 460kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
• Content And Storage: Store at 4°C in the dark.