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Tocris Bioscience™ KYA 1797K

Wnt/β-catenin signaling inhibitor

$78.80 - $310.00

Specifications

CAS 1956356-56-1
Chemical Name or Material (5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt
Molecular Formula C17H11KN2O6S2
Purity 98%
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
70-022-5
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Tocris Bioscience™
7002/25
25 mg
Each for $310.00
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70-025
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Tocris Bioscience™
7002/5
5 mg
Each for $78.80
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Description

Description

  • Wnt/β-catenin signaling inhibitor (IC50 = 0.75 μM).
  • Increases binding affinity of β-catenin for axin, GSK-3β and β-TrCP.
  • Promotes formation of the destruction complex, activation of GSK-3β and phosphorylation of β-catenin and K-Ras, leading to their degradation via the ubiquitin/proteasome system.
  • Reduces levels of β-catenin and K-Ras and inhibits growth of colorectal cancer (CRC) cells in vitro and in mouse xenograft models.
Specifications

Specifications

1956356-56-1
(5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt
C17H11KN2O6S2
98%
SDS
Product Certifications
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