Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

L-168,049, Tocris Bioscience™

Catalog Number p-4784076
Click to view available options
Quantity:
10 mg
50 mg
This item is not returnable. View return policy
191034-25-0
C24H20BrClN2O
467.791
HHBOWXZOLYQFNY-UHFFFAOYSA-N
glucagon receptor antagonist ii, 4-3-5-bromo-2-propoxyphenyl-5-4-chlorophenyl-1h-pyrrol-2-yl pyridine, 2-4-pyridyl-5-4-chlorophenyl-3-5-bromo-2-propyloxyphenyl pyrrole, d0m3ar, glucagon antagonists diabetes, glucagon antagonists diabetes , merck & co, 4-3-5-bromo-2-propoxy-phenyl-5-4-chloro-phenyl-1h-pyrrol-2-yl-pyridine
5311276
4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine
CCCOC1=C(C=C(C=C1)Br)C2=C(NC(=C2)C3=CC=C(C=C3)Cl)C4=CC=NC=C4
This item is not returnable. View return policy
191034-25-0
C24H20BrClN2O
467.791
HHBOWXZOLYQFNY-UHFFFAOYSA-N
glucagon receptor antagonist ii, 4-3-5-bromo-2-propoxyphenyl-5-4-chlorophenyl-1h-pyrrol-2-yl pyridine, 2-4-pyridyl-5-4-chlorophenyl-3-5-bromo-2-propyloxyphenyl pyrrole, d0m3ar, glucagon antagonists diabetes, glucagon antagonists diabetes , merck & co, 4-3-5-bromo-2-propoxy-phenyl-5-4-chloro-phenyl-1h-pyrrol-2-yl-pyridine
5311276
4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine
CCCOC1=C(C=C(C=C1)Br)C2=C(NC(=C2)C3=CC=C(C=C3)Cl)C4=CC=NC=C4

Potent, orally active human glucagon receptor antagonist

Very potent and selective, non-competitive antagonist of the human glucagon receptor (hGR). Binds with high affinity to human GR (IC50 = 3.7 nM), and moderate affinity to murine and canine GRs (IC50 values are 63 and 60 nM respectively). In contrast, displays poor affinity for rat, guinea pig, and rabbit glucagon receptors (IC50 > 1 μM). In functional studies, inhibits glucagon-stimulated cAMP synthesis in CHO cells expressing hGR (IC50 = 41 nM), and in murine liver membranes. Orally active in vivo.
Quantity 10 mg
Formula Weight 467.79
Percent Purity >99%
Chemical Name or Material L-168, 049
Recommended Storage Store at Room Temperature
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit