Very potent and selective beta3 partial agonist
Manufacturer: Tocris 2197/50
DescriptionPotent β3-adrenergic receptor partial agonist > 1000-fold selective over β1- and β2-adrenoceptors (EC50 values are 0.43, 580 and > 10000nM for activation of cloned human β3-, β1- and β2-adrenoceptors respectively). Stimulates lipolysis in rhesus adipocytes in vitro (EC50 = 3.9nM). Enhances CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs).
- Chemical Name: 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide
- Formula: C30H40N4O6S
- CAS Number: 159182-43-1
- Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
- Purity: >98
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