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  8. L(+)-Amethopterin hydrate, 99%, Thermo Scientific Chemicals

L(+)-Amethopterin hydrate, 99%, Thermo Scientific Chemicals

Catalog Number AC208100250
Click to view available options
Quantity:
25 mg
100 mg
500 mg
Packaging:
Glass Bottle
133073-73-1
C20H22N8O5
454.45
MFCD00150847
FBOZXECLQNJBKD-UGPWUYPHNA-N
l +-amethopterin dihydrate, methotrexate dihydrate, dihydrate methotrexate, 2s-2-4-2,4-diaminopteridin-6-yl methyl methylamino phenyl carbonylamino pentanedioic acid, hydrate, hydrate
45157423
(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;dihydrate
CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
133073-73-1
C20H22N8O5
454.45
MFCD00150847
FBOZXECLQNJBKD-UGPWUYPHNA-N
l +-amethopterin dihydrate, methotrexate dihydrate, dihydrate methotrexate, 2s-2-4-2,4-diaminopteridin-6-yl methyl methylamino phenyl carbonylamino pentanedioic acid, hydrate, hydrate
45157423
(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;dihydrate
CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

Description

L(+)-Amethopterin hydrate, CAS # 133073-73-1, is an effective inhibitor of dihydrofolate reductase, which may have anti-tumor activity.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description
• L(+)-Amethopterin hydrate, is a potent inhibitor of dihydrofolate reductase
• It has tumoricidal activity
Applications
• L(+)-Amethopterin hydrate is an inhibitor of dihydrofolate reductase
• It can be used in anti-tumor studies
• It is a cell cycle arrest agent, which can inhibit synthesis of DNA, RNA, and proteins
• It can also inhibit production of pro-inflammatory cytokines
TRUSTED_SUSTAINABILITY
Melting Point 195°C
Color Yellow to Orange
Infrared Spectrum Authentic
Assay Percent Range 98.5% min. (HPLC)
Packaging Glass Bottle
Quantity 25 mg
Merck Index 14, 5985
Specific Rotation + 21.5
Solubility Information Solubility in water: insoluble in water. Other solubilities: insoluble in alcohol,chloroform,ether,slightly soluble in dilute hydrochloric acid,soluble in dilute solutions of alkali hydroxides a
Formula Weight 454.44
Percent Purity 99%
Physical Form Crystalline Powder
Chemical Name or Material L(+)-Amethopterin hydrate
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Safety and Handling

Hazard Category GHS Signal Word: Danger
Hazard Statement GHS H Statement:
Toxic if swallowed.
May cause genetic defects.
May damage the unborn child.
Precautionary Statement GHS P Statement:
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
Obtain special instructions before use.
IF exposed or concerned: Get medical advice/attention.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
SDS

RUO – Research Use Only

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