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L-Selectin/CD62L Mouse anti-Human, Bovine, Canine, Primate, Alexa Fluor™ 594, Clone: FMC46, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NB10065388AF594

Catalog No. N106388A94


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Description

Description

L-Selectin/CD62L Monoclonal antibody specifically detects L-Selectin/CD62L in Human, Bovine, Canine, Primate samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Frozen).
Specifications

Specifications

L-Selectin/CD62L
FMC46
Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen
Conjugated, Purified
SELL
PHA stimulated lymphoblasts.
Protein G purified
Adaptive Immunity, B Cell Development and Differentiation Markers, Immunology, Lipid and Metabolism, Myeloid derived Suppressor Cell, Signal Transduction
Primary
6402.0
Bovine, Canine, Human, Primate
Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Frozen)
Alexa Fluor™ 594
50 mM sodium borate with 0.05% sodium azide
CD62L, CD62L antigen, gp90-MEL, hLHRc, LAM-1, LAM1LECAM1, Leu-8, LEU8, Leukocyte adhesion molecule 1, Leukocyte surface antigen Leu-8, Leukocyte-endothelial cell adhesion molecule 1, LNHRTQ1, LSEL, L-selectin, Lyam-1, LYAM1CD62 antigen-like family member L, Lymph node homing receptor, lymphocyte adhesion molecule 1, pln homing receptor, PLNHR, selectin L
Mouse
IgG2b
0.1 mL
Store at 4°C in the dark.
Monoclonal
NB100-65388 recognizes human CD62L, also known a L-selectin, a 74-95kDa member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes. CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naive lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains. The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.
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